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Sunday, November 13, 2011

Indo-Asian scenario of microbes, infections, antibiotics and resistance - By Dr. A. J. Tamhankar (Research Associate: Sandeep Nerkar)

Watch out for sexually transmitted 'superbug': expert Manoramaonline....."Surveillance of the anti-microbial resistance (AMR) in gonorrhea is currently being researched and India needs to be cautious about this as well," Gupta ...  
Malaysia – South East Asia– ReAct: joint education project launched  
India leads world with 25 lakh TB cases, says WHO- The Asian Age.......The five countries with the highest incidence in 2010 were India (2.5 million) ...bacterial infection that can be treated with a reliable antibiotic regime ...  
Superbug beats drugs, claims fourth life-Independent Online....... isan enzyme that makes bacteria resistant to a wide range of antibiotics, ... and infection prevention precautions were being observed. 
Superbug may be 'more widespread'- Times LIVE......NDM-1is an enzyme produced by bacteria, making bacteria resistant to antibiotics. On Saturday, a fourth patient infected with the enzyme died at the ... 
Superbug: no cause for panic- Times LIVE.......NDM-1is an antibiotic-resistant enzyme produced by specific bacteria. Of the 10 patients who tested ... NDM-1 was first identified in New Delhi, India. ... 
Can we find cure to these scourges?- Deccan Herald.......Moreover,India also has the largest multi-drug resistant tuberculosis ...when the tuberculosis bacteria develop resistance to one or several antibiotics. ... 
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Friday, November 4, 2011

Indo-Asian scenario of microbes, infections, antibiotics and resistance - By Dr. A. J. Tamhankar (Research Associate: Sandeep Nerkar)

ReAct group :Focus on Antimicrobial Resistance In Asia

Ban on antibiotics for crops likely in India 

INDIA: HealthMinister confirms the presence of antibiotic-resistant “superbug”-IMTJ...Theresearch team followed up with a report in April that found evidence of NDM-1positive bacteria in Delhi's water supply. They suggest ..........overuse of antibioticsand a lack of infection control procedures...
New discoveries ondrug resistance in Leishmania-News-Medical.net.......... that only a smallnumber of genes may cause different symptoms of infection. ... Nepal and India that had different responses to antibiotic medications. ... 
Different paths todrug resistance in Leishmania-EurekAlert.......The team used this as areference framework to analyse a further 16 isolates from Nepal and India thathad different responses to antibiotic medications. ... 
Deadly bug hits SouthAfrica-Times LIVE.....infection control measures and "prudent antibioticusage" were critical factors in reducing the "ongoing emergence"of antibiotic resistance worldwide.  NDM-1 originated in India.. 
Wanted: Better,safer, cheaper TB drugs- Arab News........In case of HIV/TB co-infection theproblem gets compounded due to severe drug-... In 2011, additional sites wereopened in India, China and Africa, ... 
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Indian Antibiotic Resistance Scenario - 2008 (by A.J. Tamhankar)

From the Scientific Journals

Human-2008.

-Antibiotic resistance calls for better diagnostic labs.
-Antibiotic resistance in pathogens causing urinary tract infections in India.
-Antibiotic resistance pattern of group-a beta-hemolytic streptococci isolated from north Indian children.

-Emerging antibiotic resistance in bacteria with special reference to India.
-Incidence of metallo beta lactamase producing Pseudomonas
aeruginosa in ICU patients.
-Estimation of faecal carriage of Clostridium difficile in patients
with ulcerative colitis using RT-PCR.
-Detection of extended spectrum beta-lactamase from clinical isolates in Davangere.
-A study on nosocomial pathogens in ICU with special reference to multiresistant Acinetobacter baumannii harbouring multiple plasmids.
-Enterococcal infections & antimicrobial resistance.
-Changing pattern of Clostridium difficile associated diarrhoea in a tertiary care hospital: A 5 year retrospective study.
-Antibiotic sensitivity pattern in cases of enteric fever.
-Functional assignment to JEV proteins using SVM.
-High rate of mutation K103N causing resistance to nevirapine.
-Increased prevalence of extended spectrum beta lactamase producers in neonatal septicaemic cases.
-Correlation between biofilm production and multiple drug resistance in imipenem resistant clinical isolates of Acinetobacter baumannii.
-Detection of Pseudomonas aeruginosa isolates producing VEB-type extended-spectrum beta-lactamases.
-Drug susceptibility testing of Mycobacterium tuberculosis against second-line drugs using the Bactec MGIT 960 System.
-Expression, purification, crystallization and preliminary X-ray diffraction studies of glyceraldehyde-3-phosphate dehydrogenase 1 from methicillin-resistant Staphylococcus aureus (MRSA252).
-Study of metallo-beta-lactamase production in clinical isolates of Pseudomonas aeruginosa.
-Occurrence of ESBL & Amp-C b-lactamases & susceptibility to newer antimicrobial agents in complicated UTI.
-Pneumonia in a traveller coming back from Asia.
-Rising prevalence of enteric fever due to multidrug-resistant Salmonella.
-Risk factors for antibiotic-resistant E. coli in children in a rural area.
-Status of high level aminoglycoside resistant Enterococcus faecium and Enterococcus faecalis.
-Synergy of gatifloxacin with cefoperazone and cefoperazone-sulbactam against resistant strains of Pseudomonas aeruginosa.
-The cost-effectiveness of typhoid Vi vaccination programs.
-The influence of glucose added urine on the in vitro antimicrobial activity of various antibiotics.
-Trend of antibiotic resistance of Vibrio cholerae strains from East Delhi.
-Triple therapy-based targeted nanoparticles for the treatment of Helicobacter pylori.
-Tigecycline in-vitro susceptibility and antibiotics' fitness for gram-negative pathogens.
-Antibiotic resistance pattern of group-a beta-hemolytic streptococci isolated from north Indian children.
-Detection and identification of methicillin resistant Staphylococcus aureus.
-Changing characteristics of Vibrio cholerae: emergence of multidrug resistance and non-O1, non-O139 serogroups.
-Dental therapeutic systems.
-Incidence of metallo beta lactamase producing Pseudomonas aeruginosa in ICU patients.
-Antibiotic prescribing practices in primary and secondary health care facilities in Uttar Pradesh, India.
-Mycobacterium tuberculosis interactome analysis unravels potential pathways to drug resistance.
-TEM & SHV genes in extended spectrum beta-lactamase producing Klebsiella species beta their antimicrobial resistance pattern.
-TargetTB: a target identification pipeline for Mycobacterium tuberculosis through an interactome, reactome and genome-scale structural analysis.
-Detection of virulence genes in Vibrio cholerae isolated from aquatic environment in Kerala, Southern India.
-Bacterial persistence: some new insights into an old phenomenon.
-Down regulation of gyrase A gene expression in E. coli by antisense ribozymes using RT-PCR.
-Novel mutations in emb B gene of ethambutol resistant isolates of Mycobacterium tuberculosis: a preliminary report.
-A potential plasmid-curing agent, 8-epidiosbulbin E acetate, from Dioscorea bulbifera L. against multidrug-resistant bacteria.
-RpoN gene, RAPD profile, antimicrobial resistance and plasmids of Vibrio anguillarum isolates from vibriosis infected Penaeus monodon.
-Novel and potent oxazolidinone antibacterials featuring 3-indolylglyoxamide substituents.
-Enhancement of the efficacy of erythromycin in multiple antibiotic-resistant gram-negative bacterial pathogens.
-Zinc and antibiotic resistance: metallo-beta-lactamases and their synthetic analogues.
-Changing trends in bacteriology of peritonsillar abscess.
-Incidence of bacterial enteropathogens among hospitalized diarrhea patients from Orissa, India.
-Moonlighting function of glutamate racemase from Mycobacterium tuberculosis: racemization and DNA gyrase inhibition are two independent activities of the enzyme.
-Substituted 3-((Z)-2-(4-nitrophenyl)-2-(1H-tetrazol-5-yl) vinyl)-4H-chromen-4-ones as novel anti-MRSA agents: synthesis, SAR, and in-vitro assessment.
-Antimicrobial stewardship in institutions and office practices.
-Tigecycline: a critical update.
-Cefoxitin disc diffusion test for detection of meticillin-resistant staphylococci.
-In-vitro antimycobacterial drug susceptibility testing of non-tubercular mycobacteria by tetrazolium microplate assay.
-Differential expression of ompC and ompF in multidrug-resistant Shigella dysenteriae and Shigella flexneri by aqueous extract of Aegle marmelos, altering its susceptibility toward beta-lactam antibiotics.
-Comparative bacteriology of acute and chronic dacryocystitis.
-Extensively drug-resistant tuberculosis: current challenges and threats.
-Prevalence of inducible clindamycin resistance in gram positive organisms in a tertiary care centre.
-Assessment of pheromone response in biofilm forming clinical isolates of high level gentamicin resistant Enterococcus faecalis.
-Incidence of carbapenem-resistant Pseudomonas aeruginosa in diabetes and cancer patients.
-Evaluation of rapid MTT tube method for detection of drug susceptibility of Mycobacterium tuberculosis to rifampicin and isoniazid.
-Phenotypic detection of inducible clindamycin resistance among Staphylococcus aureus isolates by using the lower limit of recommended inter-disk distance.
-Prevalence of extended spectrum beta lactamase and AmpC beta lactamase producers among Escherichia coli isolates in a tertiary care hospital in Jaipur.
-Empiric antibiotic therapy in children with community-acquired pneumonia.
-Comparison of the radiometric BACTEC 460 TB culture system and Löwenstein-Jensen medium for the isolation of mycobacteria in cutaneous tuberculosis and their drug susceptibility pattern.
-Molecular cloning, overexpression and biochemical characterization of hypothetical beta-lactamases of Mycobacterium tuberculosis H37Rv.
-Molecular characterization of multidrug-resistant Shigella species isolated from epidemic and endemic cases of shigellosis in India.
-Epidemiological evidence of multidrug-resistant Shigella sonnei colonization in India by sentinel surveillance in a Japanese quarantine station.
-Aminoglycoside-resistance mechanisms in multidrug-resistant Staphylococcus aureus clinical isolates.
-Antimicrobial resistance pattern of Neisseria gonorrhoeae isolates from peripheral health centres and STD clinic attendees of a tertiary care centre in India.
-Novel structural analogues of piperine as inhibitors of the NorA efflux pump of Staphylococcus aureus.
-Salmonella enterica Serotype typhi in Kuwait and its reduced susceptibility to ciprofloxacin.
-Synthesis and antimycobacterial activity of 4-[5-(substituted phenyl)-4, 5-dihydro-3-isoxazolyl]-2-methylphenols.
-Observations on carbapenem resistance by minimum inhibitory concentration in nosocomial isolates of Acinetobacter species: an experience at a tertiary care hospital in North India.
-A simple and effective approach for the treatment of chronic wound infections caused by multiple antibiotic resistant Escherichia coli.
-Cefepime and its role in pediatric infections.
-Antimicrobial susceptibility profile of resistance phenotypes of Neisseria gonorrheae in India.

-Stationary phase induced alterations in mycobacterial RNA polymerase assembly: A cue to its phenotypic resistance towards rifampicin.
-Epidemiology, etiology, and diagnosis of hospital-acquired pneumonia and ventilator-associated pneumonia in Asian countries.
-Involvement of O8-antigen in altering beta-lactam antibiotic susceptibilities in Escherichia coli.
-Prevalent phenotypes and antibiotic resistance in Escherichia coli and Klebsiella pneumoniae at an Indian tertiary care hospital: plasmid-mediated cefoxitin resistance.
-Cellphones as reservoirs of nosocomial pathogens.
-A case of fatal acute pyogenic meningitis in a neonate caused by extended-spectrum beta-lactamase producing Salmonella group B.
-Significance of isolation and drug susceptibility testing of non-Candida albicans species causing oropharyngeal candidiasis in HIV patients.
-Small and lethal: searching for new antibacterial compounds with novel modes of action.
-On detection and assessment of statistical significance of Genomic Islands.
-A study of typhoid fever in five Asian countries: disease burden and implications for controls.
-Vibrio cholerae non-O1, non-O139 strains isolated before 1992 from Varanasi, India are multiple drug resistant, contain intSXT, dfr18 and aadA5 genes.
-Emerging resistance to newer antimicrobial agents among Shigella isolated from Finnish foreign travellers.
-Antimicrobial protein from Streptomyces fulvissimus inhibitory to methicillin resistant Staphylococcus aureus.
-Modified PAP method to detect heteroresistance to vancomycin among methicillin resistant Staphylococcus aureus isolates at a tertiary care hospital.
-Detection of Enterobacteriaceae producing CTX-M extended spectrum beta-lactamases from a tertiary care hospital in south India.
-Need for national/regional guidelines and policies in India to combat antibiotic resistance.
-ESBLs detection in clinical microbiology: why & how?
-Detection of extended spectrum beta-lactamase production in clinical isolates of Klebsiella spp.
-Detection of extended-spectrum beta-lactamase in Pseudomonas aeruginosa.
-Sequence analysis of bla CTX-M-28 , an ESBL responsible for third-generation cephalosporin resistance in Enterobacteriaceae, for the first time in India.
-Spectrum of microbial flora in diabetic foot ulcers.
-Incidence of metallo-beta-lactamase-producing Pseudomonas aeruginosa in diabetes and cancer patients.
-Emergence of highly fluoroquinolone-resistant Salmonella enterica serovar Typhi in a community-based fever surveillance from Kolkata, India.
-Enteric fever in Mumbai--clinical profile, sensitivity patterns and response to antimicrobials.
-Diarrhoeal outbreak of Vibrio cholerae 01 Inaba in Delhi.
-The role of antibiotic prophylaxis in mesh repair of primary inguinal hernias using prolene hernia system: a randomized prospective double-blind control trial.
-Antimycobacterial activities of novel 2-(sub)-3-fluoro/nitro-5,12-dihydro-5-oxobenzothiazolo[3,2-a]quinoline-6-carboxylic acid.
-Staphylococcus aureus ocular isolates from symptomatic adverse events: antibiotic resistance and similarity of bacteria causing adverse events.
-Quinolone resistance among Shigella spp. isolated from travellers returning from India.
-Pneumocephalus as a complication of multidrug-resistant Klebsiella pneumoniae meningitis.
-Occurrence and detection of AmpC beta lactamases among clinical isolates of E. coli and K. pneumoniae causing UTI.
-Low recovery rates of high-level aminoglycoside-resistant enterococci could be attributable to restricted usage of aminoglycosides in Indian settings.
-Stomatococcus mucilaginosus meningitis in a healthy 2-month-old child.
-Emergence of tetracycline-resistant Vibrio cholerae O1 serotype Inaba, in Kolkata, India.
-Emergence of fluoroquinolone-resistant Neisseria meningitidis--Minnesota and North Dakota, 2007-2008.
-Dissemination of clonally related Escherichia coli strains expressing extended-spectrum beta-lactamase CTX-M-15.
-Metallo beta lactamases in Pseudomonas aeruginosa and Acinetobacter species.
-Inhibition of DNA gyrase activity by Mycobacterium smegmatis MurI.
-Role of beta-lactamase inhibitors in enterobacterial isolates producing extended-spectrum beta-lactamases.
-High nasopharyngeal carriage of beta-lactamase-negative ampicillin-resistant Haemophilus influenzae in north Indian school-going children.
-The yejABEF operon of Salmonella confers resistance to antimicrobial peptides and contributes to its virulence.
-Pre-admission antibiotics for suspected cases of meningococcal disease.
-Resistance in gram-negative bacilli in a cardiac intensive care unit in India: risk factors and outcome.
-Microbiological profile of donor corneas: a retrospective study from an eye bank in north India.
-Preparation & characterization of solid inclusion complex of cefpodoxime proxetil with beta-cyclodextrin.
-High level ciprofloxacin resistance in Salmonella enterica isolated from blood.
-Changing patterns of Vibrio cholerae in sevagram between 1990 and 2005.
-Piperine analogs as potent Staphylococcus aureus NorA efflux pump inhibitors.
-Rising standards for tuberculosis drug development.
-Transcriptional activation and increased mRNA stability contribute to overexpression of CDR1 in azole-resistant Candida albicans.
-High rate of detection of high-level aminoglycoside-resistant enterococci from urinary tract specimens in South India.

-Metallo beta lactamases in Pseudomonas aeruginosa and Acinetobacter species.
-Orthodox and unorthodox clavulanate combinations against extended-spectrum beta-lactamase producers.
-Prevalence and clonality of extended-spectrum beta-lactamases in Asia.

Non-Human and General-2008.

-Evaluation of the probiotic characteristics of newly isolated lactic acid bacteria.
-Antibiotic Resistance Pattern of Shiga Toxin-producing Escherichia coli Isolated from Diarrheic Calves in Gujarat,India.
-Detection of conjugative plasmids and antibiotic resistance genes in anthropogenic soils from Germany and India.
-Need for guidelines and policies in India to combat Antibiotic Resistance
-Diversity of root associated microorganisms of selected medicinal plants and influence of rhizomicroorganisms on the antimicrobial property of Coriandrum sativum.
-Multiple antibiotic resistance patterns of rhizospheric bacteria isolated from Phragmites australis.
-Antibiotic use, environment and antibiotic resistance: A qualitative study among human and veterinary health care professionals in Orissa, India.
-Multiple antibiotic resistance patterns of rhizospheric bacteria isolated from Phragmites australis growing in constructed wetland for distillery effluent treatment.
-In vitro activity of eugenol, an active component from Ocimum sanctum, against multiresistant and susceptible strains of Neisseria gonorrhoeae.
-Synergism between natural products and antibiotics against infectious diseases.
-Phosphinothricin resistance in Aspergillus niger and its utility as a selectable transformation marker.
-Utility of lytic bacteriophage in the treatment of multidrug-resistant Pseudomonas aeruginosa septicemia in mice.
-Conjugative plasmids in multi-resistant bacterial isolates from Indian soil.
-Selection of genes of Mycobacterium tuberculosis upregulated during residence in lungs of infected mice.
-Contamination of potable water distribution systems by multiantimicrobial-resistant enterohemorrhagic Escherichia coli.
-Antibacterial activity of some medicinal plant extracts.
-Prevalence and characterization of Salmonella enterica serovar Weltevreden from imported seafood.
-Utilization of Bombyx mori larvae as a surrogate animal model for evaluation of the anti-infective potential of oxazolidinones.